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Tissue Barriers 4:e1154641
It occurs when the immune system attacks the myelin sheath, the protective covering around nerve fibers, causing inflammation and damage
doi: 10.1016/j.talanta.2006.11.034
Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy
Free heme, even at 50100 M concentration, is a toxic molecule due to its ability to generate ROS (Gutteridge and Smith, 1988) catalyzing the oxidation of proteins, the formation of cytotoxic lipid peroxides via lipid peroxidation and damaging DNA (reviewed in Kumar and Bandyopadhyay, 2005)