Vigorous shaking or vortexing creates immense mechanical stress
References 1) Varani J, et al
This suggests that we should consider the potential for these drugs to benefit patients in more ways than just the well-established metabolic and cardiac effects. Quandt and colleagues collected data from adults with type 2 diabetes who were diagnosed with a cancer that was ranked in the top 10 causes of cancer-related death for men and women
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For example, metformin, a firstline agent in PCOS for insulin resistance, has been shown in patients with type 2 diabetes to blunt NET formation: in vitro, metformin prevented chromatin decondensation and DNA release and in vivo reduced circulating NET biomarkers (e.g., dsDNA, citrullinated histone H3) independent of glucoselowering effects [93]
Keep tablets in their original container at room temperature