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95% CI: 0.711.11)

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While GLP-1 based therapies are highly effective at managing weight reduction, gastrointestinal (GI) side effects, including nausea (2544 %), diarrhea (1932 %), vomiting (825 %), constipation (1223 %) and abdominal pain (510 %), were common in pivotal Phase 3 studies, although generally transient in nature [[40], [41], [42],46]

Current evidence indicates that ME/CFS patients exhibit significant alterations in T cell metabolism and function, characterized by mitochondrial dysfunction, reduced glycolytic activity, and upregulation of exhaustion markers [53, 203, 204]

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