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The androgen-dependent nature of this condition centers around dihydrotestosterone (DHT), a potent derivative of testosterone

PRP remains the standard treatment for PDR, but it may lead to permanent peripheral visual field loss, reduced night vision, or worsen existing DME, increasing its occurrence [37]

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Seek urgent medical attention if you develop jaundice, severe abdominal pain, dark urine, pale stools, or fever whilst taking these medications

doi:10.1210/clinem/dgab892

One of the mechanisms supporting this resistance is the interaction between FOXO4 and p53 within the nucleus