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DOI:10.4236/wjet.2018.63042

A total of 392 adult and pediatric subjects 12 years of age and older with CSU were evaluated for safety in three randomized, double-blind, parallel-group, multicenter, placebo-controlled, studies, Study A, B, and C, conducted under a master protocol (CUPID) for 36 weeks [see Clinical Studies (14.7)]

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It may be better to stick to the lower dose if you experience side effects or find it ineffective

In a trial called Surmount-1, researchers studied the once-weekly injectable in 2,500 adults without diabetes and found significant weight loss at 72 weeks

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