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10.1038/s41392-022-01004-z 45 GaoM.DongL.YangY.YanJ.LiangY.MaX.et al (2024)

Cell Host Microbe 8, 4454

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Bortezomib exerts its therapeutic effects in MM by binding to the 5 subunit of the 26S proteasome to inhibit the ubiquitinproteasome pathway, blocking activation of the Nuclear factor kappa-light-chain-enhancer (NF-B) of activated B cells signaling pathway, inducing mitochondrial apoptosis, and suppressing angiogenesis and bone destruction within the tumor microenvironment

Some may feel results sooner, while others may need more time