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Health Risks

The finding of increased risk with AEDs of varying mechanisms of action and across a range of indications suggests that the risk applies to all AEDs used for any indication

If roflumilast already produces weight loss on its own, and if it potentiates GLP-1 signaling in the brain region most associated with semaglutide's CNS effects, the combination has the texture of a hypothesis worth testing in animals quickly

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W., et al., Gastrointestinal Adverse Events and Weight Reduction in People With Type 2 Diabetes Treated With Tirzepatide in the SURPASS Clinical Trials, Diabetes, Obesity and Metabolism 26, no

Ciobanu N, Paietta E, Andreeff M , Papenhausen P, Wiernik PH