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Nat Rev Methods Primers 1:2

Boosting BDNF: Curcumin reverses the decrease in BDNF levels from chronic stress.[ref] Rheumatoid Arthritis: Curcumin is beneficial in reducing inflammation in RA.[ref] IL-17 and Autoimmune Risk: Curcumin was found to decrease IL-17 (in an animal study).[ref] HMGB1 and Inflammasome activation: In animal studies, Curcumin inhibits HMGB1 release .[ref][ref] Osteoarthritis: A natural TNF-alpha blocker, curcumin has been shown in several studies to be effective for osteoarthritis.[ref][ref] A clinical trial found that curcumin (500mg / 3x per day) was as effective as diclofenac for osteoarthritis but with fewer side effects.[ref] MRGPRX2 receptor on Mast Cells: Curcumin is likely a MRGPRX2 receptor blocker (animal and cell studies).[ref] Full article and details on berberine Berberine is a natural supplement with some amazing research for reducing high blood glucose levels and high cholesterol

By comparison, PT-141 nasal spray has been administered at doses starting from 7mg for the treatment of ED [10, 15]

Nevertheless, despite these doubts, and even although epigenetic age-based approaches becomes increasingly favored in the aging research, TL remains the most widely used molecular biomarker of aging now

Disagreements were resolved through discussion or by consultation with a fourth author (CS)