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There is a notable decrease in the percentage of CD56 bright cells, which are primarily responsible for cytokine secretion, including IFN- and TNF- [195,196,197]

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Women lost between 11.5% and 27.6% of their body weight depending on the dose and trial, while men lost between 8.8% and 18.9%

After oral treatment, the disease appeared to remain active, as 40.0% of patients in the placebo group and 26.7% in the adalimumab group developed at least one new erosive interphalangeal joint in 3.6% and 2.1% of their non-erosive interphalangeal joints, respectively, during the 12-month follow-up period, demonstrating that adalimumab has no therapeutic effect on degenerative OA of the hand

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