Lifestyle factors: Theres a noted link between acne and stress, and midlife can be a tension-filled time as family, work, and financial responsibilities reach their peak
Maintenance routine: GHK-Cu topical 3-4x per week (reduced from daily) BPC-157 250mcg 3-4x per week (reduced from daily) TB-500 optional periodic cycles (2-4 weeks every 3-4 months) Continue microneedling monthly This reduced protocol maintains gains while lowering costs and time commitment
But not all of Thesis blends offer clinically relevant doses, and some have as few as five ingredients in them

90-Day On / 30-Day Off This is perhaps the most widely reported cycling pattern: Use Dihexa daily for approximately 90 days (13 weeks) Discontinue completely for 30 days (4 weeks) Repeat the cycle Rationale: Allows receptor sensitivity to reset and minimizes tolerance No scientific evidence supports this particular cycle length 5-Days-On / 2-Days-Off A shorter cycle pattern used by some: Take Dihexa for 5 consecutive days, then skip 2 days Repeat weekly Provides more frequent breaks without long discontinuation Anecdotally reported to maintain responsiveness Continuous Use Some community members report continuous daily use without cycling: Effects may be maintained or may plateau Risk of tolerance development is unknown Long-term safety of continuous use is not established Important Note on Cycling The concept of receptor tolerance and its mitigation through cycling is theoretically grounded in neuropharmacology

Our injections use medical-grade nutrients and are provided under the supervision of a licensed naturopathic doctor
As of June 2026, the FDA's December 2024 Pharmacy Compounding Advisory Committee evaluation concluded that the criteria weighed against placing AOD-9604 (free base) or AOD-9604 acetate on the 503A Bulks List, and AOD-9604 is currently listed as Nominated but Withdrawn from FDA Category 2