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Hum Reprod Update 2003(9(4):387-396 ACOG

they can communicate information, sense danger when the cell energy levels drop, and are even involved in sending the final "death" message (apoptosis) when a cell is damaged beyond repair and needs to die

Some people do notice a bit of a reduction in their blood sugar control from this small dose, but the effect is generally small

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Do not push the deficit beyond 1,000 calories daily for extended periods, as extreme restriction increases the risk of lean tissue loss and metabolic adaptation

Any medication should be prescribed and monitored by a qualified physician, she says