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Short-term steroids such as a Medrol dose pack or intra-muscular injections need to be held for 4 weeks prior and 4 weeks after also

The specific gaps are: No human phase I or II trial for BPC-157 in any indication No published combination study in any model No pharmacokinetic data on subcutaneous GHK-Cu in humans No standardized outcome measures for the soft-tissue repair indications practitioners most commonly target The American College of Sports Medicine's 2023 position statement on peptide therapeutics in sports medicine did not endorse BPC-157 or GHK-Cu for any clinical use, citing insufficient human data

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So statements that topical AHK-Cu is "well tolerated" rest on the copper-peptide class generally much of it built on GHK-Cu (Pickart & Margolina 2018, PMID 29986520) and on community use, rather than on dedicated AHK-Cu safety study

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