Copper metabolism of astrocytes
In 2014, there were 422 million people with diabetes (8.5% of the global population) [4] and this number is expected to rise to 592 million by 2035 [5]
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chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease