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The 7-point SMPG postprandial increments were also significantly reduced with oral semaglutide 7 mg and 14 mg vs sitagliptin 100 mg (ESM Table 2)

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These substitutions preserve receptor affinity while enabling pharmaceutical-grade solubility

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"Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial." The Lancet, vol