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By targeting both GLP-1 and GIP receptors, Tirzepatide has the potential to more effectively address multiple aspects of metabolic syndrome than single-target therapies, making it a promising option for MASH treatment2

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In Trial 1, no statistically significant pharmacokinetic interaction was observed when oral semaglutide was co-administered with ethinylestradiol or levonorgestrel, suggesting that oral semaglutide does not have an impact on the contraceptive effect

Some pharmacies sell compounded versions of semaglutide as alternative options for patients that require custom dosing or formulations, but the FDA does not approve these medications

Spironolactone is a medication with a long history of use for several different conditions

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