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Furthermore, it provides a critical appraisal of recent human observational data, distinguishing metabolic benefits from intrinsic disease-modifying effects, and outlines the practical clinical friction points and prospective trials necessary to validate these pathways in future treatment paradigms

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Peripheral neuropathy applications including diabetic neuropathy, chemotherapy-induced neuropathy, and traumatic nerve injuries represent potential indications based on demonstrated nerve regeneration enhancement in animal models

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Horm Metab Res (1995) 27(8):3725