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Kannt & Pfenninger, Frontiers in Physiology emphasize that NAD preservation enhances oxidative metabolism, supporting sustained exercise capacity

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Yet the dosage, strain specificity, and individual gut variability mean that results are unpredictable and often underwhelming compared to FDA-studied GLP-1 medications

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These benefits appear across diverse patient populations, including those with obesity, prediabetes, and established type 2 diabetes

These types of errors can also lead to severe side effectswhich can last up to several weeks, as semaglutide has a long half-life and remains in the body for a long time