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Since ankyrin is an intermediate link between band 3 and the spectrin cytoskeleton of RBCs, the emerging competition for the binding sites leads to disruption of the connection between the band 3 protein and spectrin cytoskeleton 51

However, creatine synthesis starts mainly in the kidneys and is completed in our largest gland, the liver

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INR - or other suitable coagulation tests - should be checked weekly until the values stabilize and then monthly, in patients taking anticoagulants together with the drug