semaglutide and kidney Saving kidneys, hearts lives': Diabetes drug found to reduce risk of disease and death Ozempic picks up FDA indication

Summary: GLP-1 receptor agonists can produce clinically significant weight loss without structured exercise, though combining medication with physical activity optimises outcomes and preserves muscle mass

T.HutchinsonM.HavrdovaE.KitaM.et al (2012)

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In contrast, mirabegron is associated with moderate CYP2D6 inhibition, carries a hypertension warning, and must be swallowed whole