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50 & Target Kd: 65 pM (HGF) [1] In Vitro Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering

Conclusion: Fifty years after its initial discovery, GHK-Cu continues to generate compelling research interest for a straightforward reason: no other single peptide compound has demonstrated comparable breadth of biological activity at such low concentrations

The American Journal of Clinical Nutrition;2011 Jul Kondala R Atkuri, John J Mantovani, Leonard A Herzenberg, Leonore A Herzenberg

BioMed Research International (2015) 11

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One of the counterintuitive findings in copper peptide research is that more is not better