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Male C57BL/6J mice (aged 7 weeks) were purchased from Huafu Kang Biotechnology Co., Ltd

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A refined definition of astrocyte reactivity includes four key features: (1) cellular, molecular and functional changes in response to CNS insults, (2) graded responses depending on insult severity, (3) context-dependent reactions influenced by intra- and intercellular signaling and (4) beneficial or detrimental effects on surrounding cells 35

Its action on the melanocortin system, a crucial regulator of both sexual and motivational behaviors, places PT-141 at the forefront of next-generation treatments for sexual dysfunction