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Immunofluorescence staining: Cells were seeded in confocal culture dishes and divided into five experimental groups: NC (normoxia control), HY (hypobaric hypoxia), and KW6002 treatment groups (HY + 0.5 M, HY + 1 M, HY + 2 M)

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In the yeast and mammalian cytosol, the thioredoxin pathway was considered to be the major reductive pathway with the glutaredoxin/glutathione system having only a back-up or auxiliary role [38, 40]

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If a drug is in a lipid-soluble form during passage through the renal tubule, a significant fraction will be reabsorbed by passive diffusion across membranes and back into the blood