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Changes in Blood Profile from Steady State in Patients with Sickle Cell Anemia Admitted for Vaso-occlusive Crisis and Acute Chest Syndrome

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In contrast to many studies in which IGFBP-3 is tumor-suppressive, IGFBP-3 seems to act as an oncogene in gastrointestinal stromal tumors (GIST), in which low expression of miR-186 is proposed to increase metastasis through the upregulation of IGFBP-3 and several other metastatic genes [59]