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The first evidence demonstrating the role of the N-terminus of JAK2 in receptor interactions was shown using JAK2 mutants, lacking the 239 N-terminal residues that rendered the JAK2 mutant incapable of binding GHR or the membrane proximal region of the common chain (64, 65)

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10.1172/JCI105126 J

In general, the picture has emerged that the unique function of class III GRXs is to regulate the activity of TGACG-binding (TGA) transcription factors 25,27,28,29