Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean ME et al (2012) Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
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Evidence shows that the secretion of incretin hormones may be impaired in some patients (particularly secretion of GLP-1 in obese individuals), but the major responsible factor is a loss of beta cell responsiveness to the incretin hormones [4]
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A drug that works as an agonist activates the same cell receptors as the bodys natural hormones