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The logic is that bupropion + naltrexone (Contrave) addresses reward-driven eating and appetite, while topiramate independently suppresses cravings through a different brain mechanism

Theyre called GLP-1 patches, sometimes referred to as a GLP-1 patch or Ozempatches, and they promise the benefits of weight-loss shots without the needles or the price tag

Administration and dosing Contrave Contrave is a pill you take by mouth, starting with 1 tablet daily for the first week and gradually increasing over 4 weeks to the full dose of 2 tablets twice daily

Persistent or severe symptoms, however, can interfere with hydration, food intake, medication absorption, and normal organ function

In the initial stages of treatment, you may still feel hungry or experience cravings, as the medication begins to regulate your appetite

However, for patients with pre-existing gastrointestinal conditions such as gastroparesis (paralyzed stomach), severe gastroesophageal reflux disease (GERD), or inflammatory bowel disease (IBD), this mechanism can exacerbate symptoms