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Human studies, while smaller in scale, support both efficacy and safety over extended periods

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Study designs comprised casecontrol, cohort, and cross-sectional studies ( Supplementary Table 3 )

Determining dosage requirements Protocol costs depend primarily on dosage

Beyond sleep, DSIP has demonstrated a remarkably broad research profile: it modulates the HPA stress axis by reducing basal cortisol and ACTH levels, enhances endogenous opioid signalling to raise pain thresholds without tolerance development, and upregulates antioxidant defence enzymes including SOD, catalase, and glutathione peroxidase

Limited long-term human studies