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1,25(OH)D facilitates the transcriptional activation of MKP5 by promoting the binding of the VDR/RXR heterodimer to the VDRE within the MKP5 promoter region [205].Building on this, 1,25(OH)D not only regulates downstream MAPK cascades via MKP5 upregulation but also interacts with transcription factors such as NF-B, NFAT, and the glucocorticoid receptor (GCR) through its VDR/RXR complex, orchestrating a multi-level anti-inflammatory response

The database used for protein identification contained the human proteome retrieved from Uniprot (accessed in November 2022, containing 20,327 sequences)

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The FDAs staff reviewers had last month said there is little evidence to support the safety and effectiveness of these peptides for their intended uses and flagged a lack of adequate human clinical trials, in contrast to Kennedys public support