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It suggests asking whether the aches began within days of starting or weeks after an increase, whether they localize to weight-bearing joints or spread across muscle groups, and whether they improve or worsen with hydration, electrolyte replacement, and movement

You can also swirl the vial in small circles on the counter

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Salminen and Isolauri, 2006)

For other vial strengths the principle is the same aim for a 1 mg/ml final concentration so the math at the syringe stays straightforward