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This has triggered a massive wave of low-priced generic alternatives from over 40 domestic pharmaceutical companies, which is expected to slash the drugs monthly cost from 8,000 to 18,000 per month to 3,0006,000 (or even lower)

Potent anti-fibrotic agent SalB suppressed autophagosome formation and autophagic flux in HSC by down-regulating the extracellular regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK), and p38-MAPK pathways, leading to decreased expression of light chain 3 II, autophagy-related gene 5 (Atg5), -SMA, and CoI (Jiang et al., 2022)

Relative to COL IV, COL I reduced MC migration and increased melanin production, while FN promoted migration and decreased both proliferation and melanin production

Reactive oxygen species promote TNF alpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

Such cumulative impact of polypharmacy involves drug-drug interactions, increased fall potential, and attenuation of antiresorptive therapy

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