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In contrast, most rat strains develop very limited injury even with much higher doses than used in mice [124]

Phenylbutyrate-induced glutamine depletion in humans: Effect on leucine metabolism

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In particular, 4IgB7-H3 is restricted to glioblastoma cells and may serve as a target for therapy, while 2IgB7-H3 presents with higher expression in recurrent glioblastoma and increases resistance to temozolomide (122)