The imbalance of gut microbiota will reduce the production of SCFAs, weaken the ability to activate SCFAs receptors, and affect GLP-1 secretion, resulting in abnormal glucose metabolism and lipid metabolism (Ma et al., 2019)
Neither semaglutide nor orlistat has a strict upper limit for how long it can be used
I also think BIOCROWNs philosophy is worth noting
The patient reported having used an herbal preparation that was sold on several websites and was marketed as promoting regular, healthy, and complete bowel movements. Among the ingredients for this intestinal formula are aloe, senna, and cascara
Total spending in the U.S
Washington, DC: National Academies Press (US) (2002)