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The treatment reduced periorbital wrinkles by 55%, outperforming placebo and vitamin K cream, with 70% of participants reporting improved firmness and clarity (Abdulghani et al., 1998)

Participants aged 18 years with scheduling lung surgery were enrolled from April 2021 to July 2021

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demonstrated increased serum adiponectin levels in a cafeteria dietinduced obesity model, interpreting this finding as a reflection of complex adipokine regulation linked to obesity-associated metabolic and nutrigenomic adaptations rather than adiposity alone 41