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Its primary function is to increase the permeability of drugs across the BBB

After 8 weeks of hyperglycemic state, further pathological changes of diabetic C57B/6 mice in microvascular structure can occur, including expansion of the mesangial matrix of renal microvasculature and rupture of the renal tubular epithelium 321 The retinal ultrastructure changes, infoldings in retinal pigment epithelium layers are decreased, and balance or proprioception are impaired due to neurovascular disease

Both routes are used in research protocols

10.2147/dddt.S319260 79 MaidaC