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However, Hinge did effectively inhibit spine formation in neurons stimulated with 10 ng/ml HGF (Figure 13B), 10 " 12 M Nlel-AnglV ( Figure 13C) or lO "12 M Dihexa ( Figure 12D) further supporting the contention that these actions are mediated by the HGF/c- Met system

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Therapy with a 5-reductase inhibitor markedly reduces the DHT content of the prostate and, in turn, reduces prostate volume and BPH symptoms