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Clinical data show that nausea and vomiting are most common during dose escalation and tend to taper off once you reach a stable dose

What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug

[57] in 2002

However, it is unclear whether these relationships are associated with cell death

A deficiency of vitamin B12 can also cause shortness of breath or heart palpitations, as well as gastrointestinal symptoms including constipation, diarrhea, appetite loss, or gas

Tan, R.J