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In this study, we investigated the oxidative stress (OS)-mediated responses of alpha mouse liver 12 (AML12) cells to 50 m polystyrene MPs (PS-MPs) and polystyrene-amine modified MPs (PS-NH 2 -MPs) at concentrations of 0, 0.05, 0.1, 0.2, and 0.5 mg/mL for a duration of 48 h

Any temperature excursion above 8C for liquid formulations or exposure to light accelerates oxidation, converting active GSH to inactive glutathione disulfide (GSSG)

PLoS Negl Trop Dis (2008) 2(11):e330

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Kidney and liver function are particularly important to assess, as these organs play a central role in processing and eliminating glutathione-bound toxins

FDA does not intend to take enforcement action against pharmacies compounding with these during the review