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By binding directly to TNF, it accelerates trimer dissociation, thereby dismantling the active ligand required for receptor engagement

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doi: 10.3389/fphar.2019.01102 Received 07 May 2019 Accepted 26 August 2019 Published 20 September 2019 Volume 10 - 2019 Edited by Deslypere Jean Paul, Besins Healthcare, Thailand Reviewed by Pooja Dhupkar, University of Texas MD Anderson Cancer Center, United States

the synthesis of stable isotope-labelled internal standards that is required for absolute quantification is not done routinely