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Importantly, none of these clinical trials were adequately powered, well-designed, or replicated to confirm the efficacy of these interventions conclusively

While pharmaceutical manufacturers conduct stability testing under various conditions, uncontrolled exposure during shippingparticularly during summer months or in hot climatesmay affect product quality

Additionally, high-fat diet-induced lipid biosynthesis enzyme induction, including , , and , is more pronounced in the livers of Nrf2 / mice [76]

Due to their potency, careful medical supervision is essential to tailor dosing, manage side effects, and determine suitability

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