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People Who Switched to Orforglipron Kept the Weight Off The trial included nearly 400 adults who were overweight or had obesity and who had already completed another large trial, SURMOUNT-5
If these benefits extend to individuals without established disease, there could be a significant reduction in morbidity and mortality across the general population
However, while GLP-1 focuses primarily on glucose metabolism and appetite, GLP-2 has a completely different set of functions centered on intestinal health
Providers also counsel patients on practical strategies to optimize GLP-1 therapy regardless of timing
Blackwell Publishing
For many adults, a practical starting point is: 2 to 4 strength sessions per week training major muscle groups consistently gradually increasing load, reps, or control starting conservatively if deconditioned This does not require bodybuilding
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