NSAIDs, like ibuprofen, for instance, cannot be used for long periods of time because they increase gastric bleeding as well as the risk for heart attack
In summary, Vitamin B12 itself does not cause weight gain
Only two very small human studies exist, and no major health authorities have approved its use467
Vitamin B12 does not raise or lower blood glucose, so it does not interfere with how you manage your diabetes, and it has no known interaction with metformin or insulin
Thats working with physiology
Symptoms of B12 Deficiency The symptoms of vitamin B12 deficiency can range from mild to severe and may include: - Fatigue and weakness - Anemia - Nerve problems like numbness and tingling - Balance issues - Cognitive difficulties, such as memory loss or difficulty thinking clearly - Mood changes, including depression - Skin problems, such as jaundice (yellowing of the skin) or a sore tongue Recognizing these symptoms early can lead you to consider B12 supplementation, but which form is the best for you