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That said, severe or lasting pain is worth bringing up with your care team right away
The injection is given in the upper arm (deltoid muscle) as an intramuscular injection
Discomfort is usually mild
Exercise naturally appears to increase MOTS-c expression
Weight management indications (Wegovy, Zepbound) are another story
The SELECT trial, published in The Lancet (October 22, 2025), provides a landmark analysis confirming that the cardioprotective benefits of semaglutide extend beyond weight loss alone. The SELECT Trial: Study Overview The SELECT trial (NCT03574597) enrolled 17,604 participants aged 45 years and above across 41 countries and 804 sites
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