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It is clear that although the production ratio between insulin and C peptide is theoretically 1, the ratio that can be computed between plasma insulin and C peptide concentrations reflects greatly the clearance kinetics of both peptides and represents a clear index between the amount of available insulin in the circulation and its release and activity from the pancreatic cells, the last represented by C peptide

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VvGST4 (A12M): VvGST4 _A12M_fw, VvGST4 _A12M_rv, VvGST4 (C13S): VvGST4_ C13S_fw, VvGST4 _C13S_rv, VvGST4 (N108H): VvGST4 _N108H_fw, VvGST4 _N108H_rv (Supplementary Table 4) using pANT20 as template

(28(6)):e13077 doi:10.1111/anec.13077

7 , eabc9781 (2021)