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Approval was granted after Zynteglo reversed blood transfusion dependency in 12 of 13 patients in early phase clinical trials [113]: a remarkable feat for genetic hematological therapies

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As before [17,18,19,20,21,22,23], we noted brain swelling, edema, large intracerebral hemorrhage and intraventricular hemorrhage in the central and lateral ventricles and considerable lesions in all brain areas