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That question is still being answered

Stroke disrupts the hypothalamic-pituitary axis, often producing hormonal imbalances that further impair recovery

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doi: 10.1021/acsnano.2c04330

An in vitro model of cerebral Ischemia-Reperfusion was established using oxygen-glucose deprivation and reoxygenation (OGD/R)

Moreover, ERRs regulate fundamental metabolic programs across the heart, liver, skeletal muscle, and other tissues