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What we can say is that the mechanistic logic is solid, the Phase 2 human data is genuinely impressive, and the glucagon receptor component does appear to add something real beyond what dual agonism achieves

GLP-1 is secreted from these cells in response to nutrient ingestion 11

Lilly also manufactures tirzepatide (Mounjaro/Zepbound), giving them unmatched experience in the GLP-1 agonist space

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Canadian Anesthesiologists Society CAS medication safety Bulletin

These data show that the various GLP-1 receptor agonists have different immunogenicity [107]

However, there is no scientific research to support these benefits specifically with the compounded medications