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In micro- and macroautophagy, the cytoplasmic phagophores that engulf various cargos is delivered to the lysosome or by an autophagosome, respectively, while in chaperone-mediated autophagy, targeted proteins binding with chaperone proteins are translocated across the lysosomal membrane [148]

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The rationale and design across its trials were described by Giblin and colleagues in Diabetes, Obesity and Metabolism in 2026 (PMID 41090431)