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10.1016/j.phrs.2019.104554 32

Neural regulation of bone marrow

Concentrations below 100mcg/mL demand larger draw volumes (0.51mL for a 50mcg dose), where standard 1mL insulin syringes become impractical

Midtier and advanced fibers such as pectic oligosaccharides, mannan-oligosaccharides, arabinoxylan oligosaccharides (AXOSs), beta-glucans, and arabinogalactans offer slower fermentation, improved tolerance, and stronger support for butyrate producers

Meanwhile, Novos rival Lilly has been preparing the ground for its late-stage oral GLP-1 candidate orforglipron, boosting its US and European manufacturing capabilities for the drug