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How does Mounjaro (tirzepatide) work
Cost is another critical factor that may limit the availability and accessibility of targeted immunotherapy
(1) This benefit can be especially helpful for patients with mild insulin resistance or prediabetes
and long-term outcomes of patients continuing versus discontinuing GLP-1RAs perioperatively
Sixty-five percent of the participants showed histologic improvements in the appearance and distribution of elastic fibers, while they all reported improvements in perceived skin quality.8 Two earlier studies had shown both histologic improvements (solar elastosis) and clinical improvements (reduced wrinkle depth and improved skin texture and color).9,10 No clinical or histologic differences, however, were detected in an RCT (n=32) comparing oral isotretinoin (20mg 3 times/wk) combined with sunscreen and moisturizer and sunscreen and moisturizer alone.11 The authors of a more recent systematic review of 6 studies (including 3 RCTs, Table 2) (n=251) concluded that isotretinoin might be a useful treatment for skin aging.7 There is, however, insufficient evidence to recommend oral isotretinoin over topical treatments
How strong is the evidence base the article cites for this combination
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