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Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia

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To further validate the specificity of the kinase inhibitors we analyzed known substrates of the individual kinases and found good reproducibility in our dataset (Fig

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The triplication of this chromosome and of its 225 genes leads to a complex phenotype that includes particular craniofacial features, hypotonia, cardiac, and digestive defects, high incidence of leukemia, early onset of Alzheimers disease and intellectual disability (ID)

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